Chloride regulation refers to the body's ability to maintain appropriate levels of chloride, an essential electrolyte found in bodily fluids. It plays a crucial role in maintaining fluid balance, transmitting nerve signals, and supporting muscle function. The kidneys are primarily responsible for regulating chloride levels by filtering excess amounts from the blood and excreting them in urine. Disruptions in chloride regulation can lead to health issues. Low levels, known as hypochloremia, can result from conditions like prolonged vomiting or certain medications, while high levels, or hyperchloremia, may occur due to dehydration or kidney problems. Maintaining proper chloride balance is vital for overall health.