Catechol-O-Methyltransferase (COMT) is an enzyme that plays a crucial role in the metabolism of catecholamines, which are important neurotransmitters like dopamine, norepinephrine, and epinephrine. By transferring a methyl group to these compounds, COMT helps regulate their levels in the brain and body, influencing mood, cognition, and stress responses. COMT is found in various tissues, including the liver and brain, and exists in two forms: soluble and membrane-bound. Genetic variations in the COMT gene can affect enzyme activity, leading to differences in individual responses to stress and susceptibility to certain mental health conditions, such as schizophrenia and depression.