The Cassadine family is a fictional family from the soap opera General Hospital. They are known for their wealth, power, and involvement in various criminal activities. The family has a long history of feuds and rivalries, particularly with the Spencer family, which adds drama to the show's storyline. Key members of the Cassadine family include Helena Cassadine, the matriarch known for her manipulative nature, and her sons Stefan and Nikolas Cassadine. The family's legacy includes a mysterious island and a history of seeking revenge, making them one of the most notorious families in the series.