Biginelli reaction
The Biginelli reaction is a chemical process that combines an aldehyde, a β-ketoester, and a urea or thiourea to form dihydropyrimidinones. This reaction is significant in organic chemistry for synthesizing pyrimidine derivatives, which are important in pharmaceuticals and agrochemicals.
Typically, the reaction occurs under mild conditions and can be catalyzed by various acids. The resulting compounds have diverse biological activities, making the Biginelli reaction a valuable tool for researchers in drug development and medicinal chemistry.