Asfarviridae is a family of viruses known for causing diseases in animals, particularly in pigs. The most notable member of this family is the African swine fever virus (ASFV), which leads to a severe and often fatal disease in domestic and wild pigs. ASFV is highly contagious and can spread rapidly, posing significant risks to the swine industry. These viruses are characterized by their large, double-stranded DNA genomes. They are unique among DNA viruses due to their ability to replicate in the cytoplasm of host cells. Understanding Asfarviridae is crucial for developing effective control measures and vaccines to protect livestock from outbreaks.