The Android Manifest is an essential XML file in every Android application. It provides crucial information about the app, such as its name, version, and permissions required to access device features like the camera or internet. This file acts as a blueprint, guiding the Android system on how to run the app. In addition to defining app properties, the Android Manifest also declares the components of the app, including activities, services, and broadcast receivers. By specifying these elements, developers ensure that the Android operating system can manage the app's lifecycle and interactions effectively.