Airborne Infection Isolation is a method used in healthcare settings to prevent the spread of infections that can be transmitted through the air. This approach is essential for diseases like tuberculosis and measles, which can linger in the air for extended periods. Patients requiring isolation are placed in a private room with specialized ventilation systems that filter and exhaust air to the outside, minimizing the risk of airborne pathogens spreading to other areas. In addition to room design, healthcare workers must wear appropriate personal protective equipment (PPE), such as N95 respirators, when entering the isolation room. This ensures their safety while caring for patients. Proper protocols and training are crucial to effectively implement Airborne Infection Isolation and protect both patients and staff from airborne diseases.