Acyl-CoA Dehydrogenase is an enzyme that plays a crucial role in the metabolism of fatty acids. It catalyzes the first step in the beta-oxidation pathway, where it converts acyl-CoA into trans-enoyl-CoA. This reaction involves the removal of two hydrogen atoms, which are transferred to FAD to form FADH2, an important energy carrier. There are several types of acyl-CoA dehydrogenases, each specific to different chain lengths of fatty acids. Deficiencies in these enzymes can lead to metabolic disorders, affecting the body's ability to break down fats for energy. This can result in various health issues, including hypoglycemia and muscle weakness.