AMD CrossFire is a technology developed by AMD that allows multiple graphics cards to work together in a single computer system. This setup enhances graphics performance by distributing the workload across the cards, resulting in smoother gameplay and improved frame rates in video games. To use CrossFire, users need a compatible motherboard and at least two AMD Radeon graphics cards. The technology can be beneficial for gamers and professionals who require high-performance graphics for demanding applications. However, not all games support CrossFire, so users should check compatibility before setting up the system.