A-to-I editing refers to a specific type of RNA editing that alters the genetic code by converting adenosine (A) to inosine (I). This process is primarily facilitated by enzymes known as adenosine deaminases acting on RNA (ADARs). Inosine is interpreted as guanosine (G) by the cellular machinery, leading to changes in protein coding and function. This editing mechanism plays a crucial role in various biological processes, including the regulation of gene expression and the development of the nervous system. A-to-I editing is particularly significant in the context of neurons, where it can influence synaptic function and plasticity.