The expression "2^6" represents the mathematical operation of exponentiation, where the base is 2 and the exponent is 6. This means that 2 is multiplied by itself 6 times: 2 × 2 × 2 × 2 × 2 × 2. The result of this calculation is 64. In practical terms, "2^6" can be seen in various contexts, such as computer science, where it often relates to binary systems. For example, 64 is significant in computing because it represents the number of unique values that can be represented with 6 bits in binary code.