110th Street is a major thoroughfare located in Manhattan, New York City. It runs east to west, stretching from the East River to the Hudson River. The street is known for its diverse neighborhoods, including parts of Harlem and Morningside Heights. Historically, 110th Street has been significant in the cultural landscape of New York. It is home to landmarks such as Central Park and the Columbia University campus. The street has also been featured in various forms of media, including music and film, highlighting its importance in the city's identity.